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APOL1 Kidney Disease 
 
It can impact you, your kidneys, and your family     

Check Your Eligibility

What is APOL1 Kidney Disease?
 

APOL1 Kidney Disease also known as APOL1- mediated kidney disease is a kidney disease associated with mutations in the APOL1 gene. APOL1 Kidney Disease is progressive, which means it gets worse over time.

The APOL1 (apolipoprotein L1) gene is a piece of your DNA that makes a protein in your immune system, which is your body’s cells and tissues that fight infection. Changes in the APOL1 gene called mutations or variants have been linked to an increased risk for developing chronic kidney disease (CKD) in people of African descent.

Everyone has two copies of the APOL1 gene. If both copies are mutated, this can cause:
 

  • Damage to parts of the kidney that filter blood
     

  • Death of the cells inside your kidneys, which causes damage and scarring in your kidneys Both can lead to kidney failure, which requires dialysis or a kidney transplant to live.








 

Clinical studies for APOL1 Kidney Disease

APOL1 Kidney Disease currently has no approved treatments.

To address this unmet need, Maze Therapeutics, is developing a new oral medication called MZE829 as a potential therapy for APOL1 kidney disease, and is looking for individuals to join a clinical study.

We're conducting this clinical trial at our research location in Snellville, GA complete the study pre-screener below and agree to be contacted if interested.

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What is your age?
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18–39
40–68
68+
Are you diagnosed with Chronic Kidney Disease?
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Have you been told by your doctor that you have protein in your urine within the past year?
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